Students currently affiliated with the SBI include:
PhD Candidates
| Samantha Chia is identifying proteins whose methylation state varies at different stages of the yeast cell cycle, to investigate the role of protein post-translational methylation as a means for the cell to regulate protein functions and/or protein-protein interactions. |
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Tim Couttas developed a method of identifying protein post-translational modifications (PTMs) using tandem mass spectrometry during his Honours year [abstract]. He is now using this approach to further identify novel PTMs, and explore the impact that they may have in the modulation of cellular processes. |
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Apurv Goel is looking at methods to effectively co-visualise various high-throughput proteomics datasets on the yeast protein interaction network. His goal is to develop a systematic way of analysing the dynamics of the interactome. |
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Jason Low uses a variety of standard molecular biology techniques such as western blots, immunoprecipitations and mass spectrometry to study protein methylation in yeast. A significant proportion of his work also focuses on the use of protein arrays to identify methylation targets in the yeast proteome. He aims to generate the first yeast methyl-proteome network and provide new insights about what proteins are methylated, their associated functional processes and their significance. |
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Sarah-Jane Schramm is completing her PhD at The University of Sydney with Graham Mann and the melanoma research program at the Westmead Millennium Institute for Medical Research and the Melanoma Institute Australia. She is spending this year with the SBI to analyse expressed gene and protein biomarkers that might classify melanomas into subgroups with distinct molecular features and clinical behaviour. Her visit to the SBI enhances that work by providing exposure to experts who can help investigate the question in a systems context. Sarah-Jane is currently examining melanoma transcriptome data to determine whether differences in network modularity can be correlated with patient outcome. |
| Daniel Yagoub is studying the interplay of phosphorylation and methylation events in the cell, using a variety of proteomic and systems-based techniques. This will shed light on the regulatory processes that govern protein methylation and the functional effects of these modifications. |
| Lin Zhang is examining the role of post-translational modifications in the regulation of protein-protein interactions, which regulate the function of many processes inside the cell. She will be using a bioinformatic approach to examine the predominance of certain modifications, the manner in which they are recognised by particular interaction domains, and the dynamics of this as a system. The study will focus the interactome of Saccharomyces cerevisiae. |