Students currently affiliated with the SBI include:
PhD Candidates
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Tim Couttas developed a method of identifying protein post-translational modifications (PTMs) using tandem mass spectrometry during his Honours year [abstract]. He is now using this approach to further identify novel PTMs, and explore the impact that they may have in the modulation of cellular processes.
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Melissa Erce is working on the characterisation of the RNA degradosome complex in the marine organism Vibrio angustum S14. In her work, she uses techniques such as immunoprecipitation, BN-PAGE and BN-PAGE/SDS-PAGE to identify the members of this protein complex.
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Apurv Goel is looking at methods to effectively co-visualise various high-throughput
proteomics datasets on the yeast protein interaction network. His goal is to develop a systematic way of analysing the dynamics of the interactome.
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Jason Low is using a variety of techniques such as native gels, isotopic labelling (SILAC) and immunochemistry as well as data mining to identify proteins that are involved in the process of methylation and demethylation in the yeast proteome. This will provide insights into how these processes affect protein-protein interaction and hence the formation or diassociation of protein complexes.
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Ignatius Pang has been exploring the dynamics of protein interaction networks by applying bioinformatics techniques on a range of high-throughput data. In his studies of post-translational modifications (PTMs), he demonstrated that most PTMs are accessible on the surface
of proteins, and are therefore likely to be involved in protein-protein interactions [abstract]. His current research involves a large-scale analysis of PTMs in yeast.
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Lin Zhang is examining the role of post-translational modifications in the regulation of protein-protein interactions, which regulate the function of many processes inside the cell. She will be using a bioinformatic approach to examine the predominance of certain modifications, the manner in which they are recognised by particular interaction domains, and the dynamics of this as a system. The study will focus the interactome of Saccharomyces cerevisiae.
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MPhil Students
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Samantha Chia is identifying proteins whose methylation state varies at different stages of the yeast cell cycle, to investigate the role of protein post-translational methylation as a means for the cell to regulate protein functions and/or protein-protein interactions.
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Honours Students
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Amy Lo is integrating various yeast protein-protein interaction datasets to create a yeast protein interaction network. Her work focuses on membrane protein and kinase-substrate interactions.
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Sally Tang is working on the co-visualisation of the protein interaction dataset with the various gene expression profiles for Helicobacter pylori. Her goal is to identify proteins that are essential and could be of interest as potential drug targets.
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