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GEOMI
GEOMI is a network visualisation and analysis platform originally developed at National ICT Australia (NICTA). The program and its source code are released under the LGPL licence. For more information, please click here.

Sample screenshot of GEOMI network

The SBI version of GEOMI enables visualisation of protein-protein interaction data in four-dimensions, and mapped with proteomic data as described in:

Goel A, Li SS, Wilkins MR (2010). Four-Dimensional Visualisation and Analysis of Protein-Protein Interaction Networks. Molecular and Cellular Proteomics, submitted.

Ho E, Webber R, Wilkins MR (2008). Interactive three-dimensional visualization and contextual analysis of protein interaction networks. Journal of Proteome Research, 7: 104-12. [abstract]

Download GEOMI (SBI version) [zip]
Requires Java and at least Java 3D 1.5.

GEOMI User Guide [pdf]

4-D Visualisation of Protein-Protein Interaction Networks
More videos can be viewed on our Youtube channel.

DNA mismatch repair proteins

Cell cycle gene expression data has been mapped onto DNA mismatch repair proteins MLH1, MSH2, MSH6, PMS1 and nearby interacting proteins in yeast.
Green: down regulation, Red: up regulation, Black: no change in expression.
Colour intensity indicates level of expression change.

Histones in the cell cycle

Cell cycle expression data mapped onto histone proteins and nearby interacting partners in yeast.
Green: down regulation, Red: up regulation, Black: no change in expression.
Colour intensity indicates level of expression change.

XWG Files
The XWG (XML Wilma Graph) file format is used by GEOMI to visualise networks.

To view these files, move the downloaded files to the data directory in GEOMI. Make sure the directory also contains the WilmaGraph.dtd file.

YEAST
README

4D_Histones.xwg

4D_MLC1.xwg

4D_DNAMismatchRepair.xwg

4D_YPT52.xwg

4D_CentralCarbon.xwg

all.xwg

all_bcc.xwg

cytoplasm.xwg

cytoplasm_bcc.xwg

mitochondria.xwg

nucleus.xwg

nucleus_bcc.xwg

4D network of histone proteins

4D network of hub protein MLC1

4D network of DNA mismatch repair proteins

4D network of hub protein YPT52

4D network of central carbon network metabolism proteins

interactome of Bertin et al. (2007) dataset [abstract]

biggest connected component of the above

interactome within the cytoplasm

biggest connected component of the above

interactome within the mitochondria

interactome within the nucleus

biggest connected component of the above