We develop and use ‘omics technology in our investigations of molecular systems biology. We have extensive expertise in proteomics and in next-gen sequencing, and the bioinformatics analysis of resulting data. We use networks to contextualise and interpret data, to understand the biology of model organisms and mammalian cells. We have extensive experience in transcriptomics and genomics. I have two labs that work together in the Systems Biology Initiative.
Projects in data analysis and integration include:
Projects in genomics and transcriptomics include:
The focus of the proteomics lab is to understand the role of post-translational modifications in protein-protein interaction networks. Our overarching hypothesis is that modifications are used extensively to modulate interactions, and in doing so regulate function. We are exhaustively studying the role of protein methylation in this regard.