18 Apr 2023

Large-scale XL-MS on the human proteome published in PNAS

Congratulations to Tara Bartolec, who recently finished her PhD with us, and to Jason Low (University of Sydney, who completed his PhD with us ~ 10 years ago) on the outstanding publication: Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Published in PNAS, the paper describes the largest XL-MS study to date for the human cell, reporting crosslinks for 4,084 unique human proteins and 2,110 unique protein-protein interactions. It also validates AlphaFold models for hundreds of human proteins with no prior structure. We enjoyed working with Joel Mackay’s lab in this collaboration. The paper is available here.