Dr Gene Hart-Smith

Project Detail

Methylation in protein interactions

I am using our existing knowledge of the S. cerevisiae intracellular methylation network to conduct an organism-wide survey of protein-protein interactions mediated by methylation. My  research makes use of an innovative mass spectrometry-based workflow, centred around a technique known as Size Exclusion Chromatography-Protein Correlation Profiling-Stable Isotope Labelling by Amino acids in Cell culture (SEC-PCP-SILAC), to monitor the role of methylation in protein complex formation.


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